Linking to MEROPS

We encourage other webmasters to make links to MEROPS. However, please note that MEROPS is a framed Web site, so links will work well only if they are constructed in the right way. They need to take advantage of a CGI program on the MEROPS Web site as described below.

Adding a page to your Favorites (Microsoft Internet Explorer) or Bookmarks (Netscape) is easy. Each page in the Database contains a JavaScript function to help you do this. Just click the link "Add this page to your Favorites" at the bottom of the page, and follow the prompts.

If you want to construct links to MEROPS from your own Web site, you will need to know that the format of every link should be like:

http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=VAR1;action=VAR2

The values of VAR1 and VAR2 are the things that you will need to specify in order to retrieve exactly the right page. First decide whether you want to link to MEROPS at the level of a peptidase or inhibitor, a family, a clan, or one of the general pages (such as an index). Select the value for VAR1 from the table below, and then (optionally) select one of the available values for VAR2. (The value of VAR1 is the more important because there are built-in defaults for VAR2 that will often be acceptable.) All the possible (i.e. valid) values are shown in Table 1 below. Some of the values are written with capital letters for clarity, but in fact the values are not case-sensitive.

When working at the peptidase/inhibitor level, please note that there are special kinds of PepCards that contain peptidase that have not yet been assigned to specific identifiers, or peptidase homologues that are known not to be catalytically active. These are stored in files with names that end in "UPW" or "UNW" respectively for a family that has not been divided into subfamilies. Thus, the members of family M1 that have not been assigned to identifiers can be found under M01.UPW, and those that are known not to be peptidases under M01.UNW. For a family that has been divided into subfamilies, there will be files for each subfamily with endings like "UPA", "UNA", "UPB" and UNB", and so on. All inhibitor homologues that have not been assigned to specific codes are stored in files ending in "UNW", "UNA", etc. according to whether the family has been divided into subfamilies.

Table 1

VAR1 (the 'id' value) VAR2 (the 'action' value) Result (page returned)
Peptidase/Inhibitor level
VAR1 is the standard MEROPS identifier for the peptidase or inhibitor.
Examples: C14.003, A9G.018, LI91-002, S08.UPA
Optionally, a point in an identifier can be replaced with "p", so that C14p003 is also valid.
Summary or default Summary for the peptidase/inhibitor
Sequences Sequences for the peptidase/inhibitor
Distribution Distribution of the peptidase/inhibitor
Structure Structure of the peptidase/inhibitor
Substrates Some substrates of the peptidase
Literature Literature for the peptidase/inhibitor
HsESTal Alignment of the human ESTs
HsESTdt Data for the human ESTs
MmESTal Alignment of the mouse ESTs
MmESTdt Data for the mouse ESTs
Family level
VAR1 is the standard MEROPS identifier for the family of peptidases or inhibitors.
Examples: A1, I25
Summary or default Summary for the family
Alignment Sequence alignment for the family
Tree Tree for the family
Genomes Occurrence of the family in whole genomes
Structure 2D structure diagrams
Literature Literature for the family
Hsseq Human sequences in the family
Mmseq Mouse sequences in the family
Animals Animal species from which the family is known
Plants Plant species from which the family is known
Viruses Viruses from which the family is known
Bacteria Bacteria from which the family is known
Archaezoa Archaezoa from which the family is known
Archaea Archaea from which the family is known
Fungi Fungi from which the family is known
Protozoa Protozoa from which the family is known
Clan level
VAR1 is the standard MEROPS identifier for the clan of peptidases or inhibitors.
Examples: AA, IM, MA(E)
Summary or default Summary for the clan
Alignment Summary sequence alignment
Structure 2D structures for the clan
Literature Literature for the clan
General pages
Main (default) default Peptidases title page
iMain default Inhibitors title page
New default What's New?
Search default Menu of Searches for peptidases
iSearch default Menu of Searches for inhibitors
Comm default Community page
Org default Organism/peptidases index
e.g. sp000033 (MEROPS identifier for an organism) Organism/peptidases summary page
iOrg default Organism/inhibitors index
e.g. sp000033 (MEROPS identifier for an organism) Organism/inhibitors summary page
Blast default BLAST menu page
about e.g. about_0 up to about_13 Page of the About documentation
Est default List of EST library indexes
[hs/mm]\d* (i.e. hs or mm followed by EMBL identifier for an EST library) Peptidase EST data for the given library
substrate e.g. P05067 (UniProt accession) Show known cleavages of this protein substrate
Index PepName Index of peptidases by name
pep[a-z] Peptidases name index, page A...Z
iNam Index of inhibitors by name
inh[a-z] Inhibitors name index, page A...Z
smi Index of small molecule inhibitors by name
gene Index of peptidases by gene name
igene Index of inhibitors by gene name
aspi, cysi, meti, seri, or txui Index of aspartic, cysteine, metallo, serine, or threonine, unknown and compound peptidase
indx Index of inhibitors by identifier
Org Index of organisms and their peptidases
iOrg Index of organisms and their inhibitors
FamId Index of peptidase families by identifier
iFamId Index of inhibitor families by identifier
ClanId Index of peptidase clans by identifier
iClanId Index of inhibitor clans by identifier
kingdist Distribution of peptidase clans and families among kingdoms of organisms
ikingdist Distribution of inhibitor clans and families among kingdoms of organisms
trail Audit trail for changed identifiers
newcode New peptidase/inhibitor identifiers
pepstat Statistics for peptidases
istat Statistics for inhibitors
peplist Peptidase List
pepimg Index of molecular images for peptidases
iimg Index of molecular images for inhibitors
esti List of EST library indexes
unseq Peptidases not allocated to families
[hs/mm]estln Index of human/mouse EST libraries by library number
[hs/mm]estts Index of human/mouse EST libraries by tissue
[hs/mm]estdv Index of human/mouse EST libraries by developmental stage
[hs/mm]estdi Index of human/mouse EST libraries by disease state


DAS server

A distribution annotation system (DAS) server has been set up to allow a user to extract data directly from the MEROPS MySQL database for inclusion in his or her own Internet service. By including a UniProt accession or EMBL or GenBank ProtID in the URL, data relating to that sequence stored in our collection will be returned. For a peptidase or protein inhibitor, this will include the MEROPS identifier, family and clan, the residue range of the peptidase or inhibitor unit, active site residues for a peptidase (and metal ligands for a metallopeptidase), the amino acid sequence and a link to MEROPS for each feature. For a protein substrate, the position of the P1 residue in each cleavage site and the MEROPS identifier of the peptidase responsible are returned. Exanmples of URLs are:

Features for human cathepsin B http://das.sanger.ac.uk/das/merops/features?segment=P07858
Sequence for human cathepsin B http://das.sanger.ac.uk/das/merops/sequence?segment=P07858
Known cleavages for human amyloid beta A4 protein precursor http://das.sanger.ac.uk/das/merops/features?segment=P05067