Clans of Inhibitors

A clan of peptidase inhibitors contains all the modern-day inhibitors that have arisen from a single evolutionary origin of inhibitors. It is a group of inhibitors in one or more families that show evidence of their evolutionary relationship by their similar tertiary structures. Each clan of inhibitors has a two-letter identifier, in which the first letter is "I". Some families cannot yet be assigned to a clan, and when a formal assignment is required, such a family is described as belonging to clan I-.

CLAN FAMILY TYPE INHIBITOR STRUCTURE
IA I1 ovomucoid inhibitor unit 3 (Meleagris gallopavo) Yes
IA I5 ascidian trypsin inhibitor (Halocynthia roretzi) Yes
IA I8 Bombyx subtilisin inhibitor (Bombyx mori) Yes
IA I88 oryctin (Oryctes rhinoceros) Yes
IB I2 aprotinin (Bos taurus) Yes
IB I52 tick anticoagulant peptide (Ornithodoros moubata) Yes
IC I3 soybean Kunitz trypsin inhibitor (Glycine max) Yes
IC I48 clitocypin (Lepista nebularis) Yes
IC I85 macrocypin 1 (Macrolepiota procera) Yes
ID I4 alpha-1-peptidase inhibitor (Homo sapiens) Yes
IE I7 trypsin inhibitor MCTI-1 (Momordica charantia) Yes
IE I37 potato metallocarboxypeptidase inhibitor (Solanum tuberosum) Yes
IF I12 Bowman-Birk inhibitor unit 1 (Glycine max) Yes
IF I67 bromein (Ananas comosus) Yes
IF I99 Bowman-Birk-like trypsin inhibitor (Odorrana versabilis) Yes
IG I13 eglin c (Hirudo medicinalis) Yes
IH I25 cystatin A (Homo sapiens) Yes
IH I47 latexin (Homo sapiens) Yes
II I27 calpastatin inhibitor unit 1 (Homo sapiens) Yes
IJ I6 ragi seed trypsin/alpha-amylase inhibitor (Eleusine coracana) Yes
IK I38 metallopeptidase inhibitor (Dickeya chrysanthemi) Yes
IK I57 staphostatin B (Staphylococcus aureus) Yes
IK I58 staphostatin A (Staphylococcus aureus) Yes
IL I39 alpha-2-macroglobulin (Homo sapiens) Yes
IM I14 hirudin (Hirudo medicinalis) Yes
IM I15 antistasin inhibitor unit 1 (Haementeria officinalis) Yes
IN I11 ecotin (Escherichia coli) Yes
IP I17 secretory leukocyte peptidase inhibitor domain 2 (Homo sapiens) Yes
IQ I50 baculovirus P35 caspase inhibitor (Spodoptera litura nucleopolyhedrovirus) Yes
IR I33 aspin (Ascaris suum) Yes
IS I46 leech metallocarboxypeptidase inhibitor (Hirudo medicinalis) Yes
IT I35 timp-1 (Homo sapiens) Yes
IU I36 Streptomyces metallopeptidase inhibitor (Streptomyces nigrescens) Yes
IV I32 survivin (Homo sapiens) Yes
IV I91 F1L protein (Vaccinia virus) Yes
IW I19 peptidase inhibitor LMPI inhibitor unit 1 (Locusta migratoria) Yes
IX I31 equistatin inhibitor unit 1 (Actinia equina) Yes
IY I16 streptomyces subtilisin inhibitor (Streptomyces albogriseolus) Yes
IZ I59 triabin (Triatoma pallidipennis) Yes
unassigned I10 marinostatin (Alteromonas sp.) Yes
unassigned I21 secretogranin V (Homo sapiens) -
unassigned I22 BsuPI peptidase inhibitor (Bacillus subtilis) Yes
unassigned I24 pinA Lon peptidase inhibitor (Enterobacteria phage T4) -
unassigned I49 proSAAS (Homo sapiens) -
unassigned I53 madanin 1 (Haemaphysalis longicornis) -
unassigned I55 squash aspartic peptidase inhibitor (Cucumis sativus) -
unassigned I64 thrombostasin (Haematobia irritans) -
unassigned I66 Lentinus peptidase inhibitor (Lentinula edodes) Yes
unassigned I69 streptopain inhibitor (Streptococcus pyogenes) Yes
unassigned I71 falstatin (Plasmodium falciparum) Yes
unassigned I72 chimadanin (Haemaphysalis longicornis) -
unassigned I74 variegin (Amblyomma variegatum) Yes
unassigned I75 bacteriophage lambda CIII protein (bacteriophage lambda) -
unassigned I76 thrombin inhibitor (Glossina morsitans) -
unassigned I77 anophelin (Anopheles albimanus) Yes
unassigned I78 Aspergillus elastase inhibitor (Aspergillus fumigatus) Yes
unassigned I79 AVR2 protein (Passalora fulva) -
unassigned I80 IseA protein (Bacillus subtilis) -
unassigned I81 toxostatin-1 (Toxoplasma gondii) -
unassigned I84 cvSI-2 (Crassostrea virginica) -
unassigned I87 HflC (Escherichia coli) -
unassigned I90 trypsin inhibitor (Mirabilis jalapa) Yes
unassigned I92 NvCI carboxypeptidase inhibitor (Nerita versicolor) Yes
unassigned I93 Sizzled protein (Xenopus laevis) Yes
unassigned I96 EAPH2 protein (Staphylococcus aureus) Yes
JA I34 saccharopepsin inhibitor (Saccharomyces cerevisiae) Yes
JB I63 pro-eosinophil major basic protein (Homo sapiens) Yes
JC I9 peptidase B inhibitor (Saccharomyces cerevisiae) Yes
JD I18 mustard trypsin inhibitor-2 (Sinapis alba) Yes
JE I51 serine carboxypeptidase Y inhibitor (Saccharomyces cerevisiae) Yes
JF I29 cytotoxic T-lymphocyte antigen-2 alpha (Mus musculus) Yes
JH I83 AmFPI-1 (Antheraea mylitta) Yes
JJ I44 metallocarboxypeptidase A inhibitor (Ascaris suum) Yes
JK I68 tick carboxypeptidase inhibitor (Rhipicephalus bursa) Yes
JL I42 chagasin (Leishmania major) Yes
JM I43 oprin (Didelphis marsupialis) Yes
JN I73 {Veronica} trypsin inhibitor (Veronica hederifolia) Yes
JO I20 potato peptidase inhibitor II inhibitor unit 1 (Solanum tuberosum) Yes