Summary for clan AF

Summary Alignment Structure Literature
Clan type peptidaseA26.001 - omptin (Escherichia coli), MEROPS Accession MER0000606 (peptidase unit: 21-317); PDB accession 1I78
HistoryMEROPS 5.7 (17 December 2001)
DescriptionWater nucleophile; water bound by Asp and His; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
Contents of clanClan AF contains a single family of membrane-inserted endopeptidases.
EvidenceThe protein fold of omptin (A26.001) from Escherischia coli is unlike that of any other peptidase, and family A26 is the single family in clan AF.
Catalytic mechanism(See family A26.)
Peptidase activity(See family A26.)
Protein foldOmptin (A26.001) is an all-beta protein with the ten strands arranged in a cylindrical barrel which is inserted into the membrane with the active site residues on the outer surface (Vandeputte-Rutten et al., 2001).
Homologous non-peptidase familiesThe outer membrane adhesin/invasin OpcA from Neisseria meningitidis has a similar fold (Prince et al., 2002).
Other databases SCOP69917


Family Family Type Peptidase Structure
A26 omptin (Escherichia coli) Yes

Distribution of clan AF among Kingdoms of Organisms