Summary for clan GA

Summary Alignment Structure Literature
Clan type peptidaseG01.001 - scytalidoglutamic peptidase (Scytalidium lignicolum), MEROPS Accession MER0001320 (peptidase unit: 58-260); PDB accession 1S2B
HistoryMEROPS 6.6 (27 March 2004)
DescriptionWater nucleophile; water bound by Gln and Glu; all endopeptidases
Contents of clanThe clan contains a glutamic endopeptidases.
EvidenceClan GA contains the only family of glutamic peptidases, G1.
Catalytic mechanism(See family G1.)
Peptidase activity(See family G1.)
Protein foldTertiary structures have been determined for aspergilloglutamic peptidase (G01.002: Sasaki et al., 2004) and scytalidoglutamic peptidase (G01.001: Fujinaga et al., 2004). These are all-beta proteins containing two beta sheets arranged in a sandwich. The partial two-fold symmetry of the structure is evidence of an ancient gene duplication event.
Homologous non-peptidase familiesThere are a number of families that have a similar fold to that of clan GA, including lectins, glucanases, sialidases and xylanases (see SCOP sunid 101656). Toxins from Clostridium, including tentoxilysin (M27.001) and bontoxilysin (M27.002) are multidomain proteins, and the N-terminal receptor binding domain also has a fold similar to that of clan GA.
Other databases SCOP49899


Family Family Type Peptidase Structure
G1 scytalidoglutamic peptidase (Scytalidium lignicolum) Yes

Distribution of clan GA among Kingdoms of Organisms