Summary for clan MP

Summary Alignment Structure Literature
Clan type peptidaseM67.010 - JAMM-like protein (Archaeoglobus-type) (Archaeoglobus fulgidus), MEROPS Accession MER0031571 (peptidase unit: 1-121); PDB accession 1OI0_A
HistoryMEROPS 6.6 (27 March 2004)
DescriptionWater nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
Contents of clanClan MP contains metallopeptidases in the single family M67.
EvidenceThe protein fold of JAMM-like protein (M67.010) from Archeaoglobus fulgidus is unlike that of any other peptidase, and family M67 is the single family in clan MP.
Catalytic mechanism(See family M67.)
Peptidase activityKnown activities are isopeptidase (see family M67).
Protein foldThe tertiary structure determined for JAMM-like protein shows a single domain consisting of a five-stranded beta sheet (in the order 21345, with strand two antiparallel to the rest) located between two helices (Tran et al., 2003).
Homologous non-peptidase familiesCytidine deaminase has a similar fold (see SCOP sunid 53926).
Other databases SCOP102712

Families

Family Family Type Peptidase Structure
M67 RPN11 peptidase (Saccharomyces cerevisiae) Yes

Distribution of clan MP among Kingdoms of Organisms

FamilyBacteriaArchaeaProtozoaFungiPlantsAnimalsViruses
M67+++++++
Clan+++++++