Summary for clan ND

Summary Alignment Structure Literature
Clan type peptidaseN04.001 - Tsh-associated self-cleaving domain (Escherichia coli) and similar (Escherichia coli), MEROPS Accession MER0187148 (peptidase unit: 1100-1377); PDB accession 3AEH_A
HistoryMEROPS 9.3 (7 September 2010)
DescriptionAsparagine nucleophile; catalytic residues in the order Asn, Glu in sequence; all self-processing endopeptidases
Contents of clanPeptidase clan ND contains autolytic endopeptidases.
EvidenceThe tertiary structure of the Tsh C-terminal propeptide (Escherichia coli; N04.001) has been solved, and shows a 12-stranded beta barrel domain unlike that of any other peptidase (Tajima et al., 2010).
Catalytic mechanism(see family N4)
Peptidase activity(see family N4)


Family Family Type Peptidase Structure
N4 Tsh-associated self-cleaving domain ({Escherichia coli}) and similar (Escherichia coli) Yes

Distribution of clan ND among Kingdoms of Organisms