Families of Inhibitors

A family is a set of homologous peptidase inhibitors. The homology is shown by a significant similarity in amino acid sequence either to the type inhibitor of the family, or to another protein that has already been shown to be homologous to the type inhibitor, and thus a member of the family. The relationship must exist in the inhibitory unit at least. A family can contain a single inhibitor if no homologues are known, and a single gene product can contain several inhibitory domains, which may be assigned to different identifiers or even families. Each family of inhibitors has an identifier formed from the letter "I" followed by a unique number. A family may be divided into subfamilies when there is evidence of a very ancient divergence within the family.

Inhibitors
FAMILY SUBFAMILY TYPE INHIBITOR
I1 ovomucoid inhibitor unit 3 (Meleagris gallopavo)
I2 aprotinin (Bos taurus)
I3 I3A soybean Kunitz trypsin inhibitor (Glycine max)
I3 I3B proteinase inhibitor B (Sagittaria sagittifolia)
I4 alpha-1-peptidase inhibitor (Homo sapiens)
I5 ascidian trypsin inhibitor (Halocynthia roretzi)
I6 ragi seed trypsin/alpha-amylase inhibitor (Eleusine coracana)
I7 trypsin inhibitor MCTI-1 (Momordica charantia)
I8 Bombyx subtilisin inhibitor (Bombyx mori)
I9 peptidase B inhibitor (Saccharomyces cerevisiae)
I10 marinostatin (Alteromonas sp.)
I11 ecotin (Escherichia coli)
I12 Bowman-Birk inhibitor unit 1 (Glycine max)
I13 eglin c (Hirudo medicinalis)
I14 hirudin (Hirudo medicinalis)
I15 antistasin inhibitor unit 1 (Haementeria officinalis)
I16 streptomyces subtilisin inhibitor (Streptomyces albogriseolus)
I17 secretory leukocyte peptidase inhibitor domain 2 (Homo sapiens)
I18 mustard trypsin inhibitor-2 (Sinapis alba)
I19 peptidase inhibitor LMPI inhibitor unit 1 (Locusta migratoria)
I20 potato peptidase inhibitor II inhibitor unit 1 (Solanum tuberosum)
I21 secretogranin V (Homo sapiens)
I22 BsuPI peptidase inhibitor (Bacillus subtilis)
I24 pinA Lon peptidase inhibitor (Enterobacteria phage T4)
I25 I25A cystatin A (Homo sapiens)
I25 I25B ovocystatin (Gallus gallus)
I25 I25C metallopeptidase inhibitor (Bothrops jararaca)
I27 calpastatin inhibitor unit 1 (Homo sapiens)
I29 cytotoxic T-lymphocyte antigen-2 alpha (Mus musculus)
I31 equistatin inhibitor unit 1 (Actinia equina)
I32 survivin (Homo sapiens)
I33 aspin (Ascaris suum)
I34 saccharopepsin inhibitor (Saccharomyces cerevisiae)
I35 timp-1 (Homo sapiens)
I36 Streptomyces metallopeptidase inhibitor (Streptomyces nigrescens)
I37 potato metallocarboxypeptidase inhibitor (Solanum tuberosum)
I38 metallopeptidase inhibitor (Dickeya chrysanthemi)
I39 alpha-2-macroglobulin (Homo sapiens)
I42 chagasin (Leishmania major)
I43 oprin (Didelphis marsupialis)
I44 metallocarboxypeptidase A inhibitor (Ascaris suum)
I46 leech metallocarboxypeptidase inhibitor (Hirudo medicinalis)
I47 latexin (Homo sapiens)
I48 clitocypin (Lepista nebularis)
I49 proSAAS (Homo sapiens)
I50 I50A baculovirus P35 caspase inhibitor (Spodoptera litura nucleopolyhedrovirus)
I50 I50B p35 homologue (Amsacta moorei entomopoxvirus)
I51 serine carboxypeptidase Y inhibitor (Saccharomyces cerevisiae)
I52 tick anticoagulant peptide (Ornithodoros moubata)
I53 madanin 1 (Haemaphysalis longicornis)
I55 squash aspartic peptidase inhibitor (Cucumis sativus)
I57 staphostatin B (Staphylococcus aureus)
I58 staphostatin A (Staphylococcus aureus)
I59 triabin (Triatoma pallidipennis)
I63 pro-eosinophil major basic protein (Homo sapiens)
I64 thrombostasin (Haematobia irritans)
I66 Lentinus peptidase inhibitor (Lentinula edodes)
I67 bromein (Ananas comosus)
I68 tick carboxypeptidase inhibitor (Rhipicephalus bursa)
I69 streptopain inhibitor (Streptococcus pyogenes)
I71 falstatin (Plasmodium falciparum)
I72 chimadanin (Haemaphysalis longicornis)
I73 {Veronica} trypsin inhibitor (Veronica hederifolia)
I74 variegin (Amblyomma variegatum)
I75 bacteriophage lambda CIII protein (bacteriophage lambda)
I76 thrombin inhibitor (Glossina morsitans)
I77 anophelin (Anopheles albimanus)
I78 Aspergillus elastase inhibitor (Aspergillus fumigatus)
I79 AVR2 protein (Passalora fulva)
I80 IseA protein (Bacillus subtilis)
I81 toxostatin-1 (Toxoplasma gondii)
I83 AmFPI-1 (Antheraea mylitta)
I84 cvSI-2 (Crassostrea virginica)
I85 macrocypin 1 (Macrolepiota procera)
I87 HflC (Escherichia coli)
I88 oryctin (Oryctes rhinoceros)
I90 trypsin inhibitor (Mirabilis jalapa)
I91 F1L protein (Vaccinia virus)
I92 NvCI carboxypeptidase inhibitor (Nerita versicolor)
I93 Sizzled protein (Xenopus laevis)
I96 EAPH2 protein (Staphylococcus aureus)
I99 Bowman-Birk-like trypsin inhibitor (Odorrana versabilis)