Family C105


Summary Holotypes Alignment Genomes Literature

Summary for family C105

Family type peptidaseC105.001 - papain-like peptidase 1 alpha (simian hemorrhagic fever virus) (simian hemorrhagic fever virus), MEROPS Accession MER0511399 (peptidase unit: 1-243)
Content of family
History Identifier created: MEROPS 9.11 (21 July 2014)
The simian hemorrhagic fever virus nonstructural polyprotein 1a includes at least three peptidases responsible for processing the polyprotein, known as papain-like peptidases PLP1alpha (C105.001), PLP1beta (C32.002) and PLP1-gamma (C32.003) (Vatter et al., 2014). Two other homologues are known, from families C33 and S32, but their physiological roles have not been determined. The sequence of PLP1alpha is not significantly similar to that of any other peptidase.
Catalytic typeCysteine
Active site residuesC115 H130 
Active siteCys115 was identified as a catalytic residue by site-directed mutagenesis (Vatter et al., 2014), and His130 is predicted to complete a catalytic dyad.
Activities and specificitiesThe PLP1alpha peptidase processes the polyprotein at Gly+Gly and Gly+Thr bonds (Vatter et al., 2014).
Molecular structureNo tertiary structure has been solved, but from the arrangement of the predicted catalytic residues, family C105 is assumed to be a member of clan CA.
Distribution of family Bacteria -  
Archaea -  
Protozoa -  
Fungi -  
Plants -  
Animals -  
Viruses details  
Biological functionsPLP1alpha performs two of the processing events required for maturation of the viral nonstructural polyprotein (Vatter et al., 2014).
Statistics for family C105Sequences:1
Identifiers with PDB entries:0
Downloadable files Sequence library (FastA format)
Peptidases and Homologues MEROPS ID Structure
papain-like peptidase 1 alpha (simian hemorrhagic fever virus)C105.001-