Family C107

Family

Summary Holotypes Genomes Literature

Summary for family C107

Family type peptidaseC107.001 - alphamesonivirus 3C-like peptidase (Cavally virus), MEROPS Accession MER0592262 (peptidase unit: 1387-1700)
Content of familyPeptidase family C107 contains viral cysteine endopeptidases.
History Identifier created: MEROPS 10.0 (14 Mar 2016)
Cavally virus and other viruses from the family Mesoniviridae are divergent members of the Nidovirales, which includes coronaviruses. Polyprotein processing requires a C3-like peptidase only distantly related to the coronavirus peptidase ( C30).
Catalytic typeCysteine
Active siteSite-directed mutagenesis has identified His1434 and Cys1539 to be the catalytic dyad (Blanck et al., 2014).
Activities and specificitiesThe 3C-like peptidase (#C107.001#) processes the large polyproteins pp1a and pp1ab. Autocatalytic release of the peptidase occurs by cleavage at -Asn-Lys+Ser- and -Asn-Gln+Ser- bonds, and presence of Asn in P2 may be a requirement (Blanck et al., 2014).
InhibitorsInhibitors have not been described.
Molecular structureNo tertiary sytructure has yet been solved. From the arrangement of catalytic dyad, family C107 in included in clan PA, subclan PA(C).
ClanPA
SubclanPA(C)
Distribution of family Bacteria -  
Archaea -  
Protozoa -  
Fungi -  
Plants -  
Animals -  
Viruses details  
Biological functionsThe peptidase is required for processing of the RNA polyproteins (Blanck et al., 2014).
Statistics for family C107Sequences:8
Identifiers:1
Identifiers with PDB entries:0
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Peptidases and Homologues MEROPS ID Structure
alphamesonivirus 3C-like peptidaseC107.001-
C107.UNW-
family C107 unassigned peptidasesunassigned-