|Family type peptidase||C107.001 - alphamesonivirus 3C-like peptidase (Cavally virus), MEROPS Accession MER0592262 (peptidase unit: 1387-1700)|
|Content of family||Peptidase family C107 contains viral cysteine endopeptidases.|
Identifier created: MEROPS 10.0 (14 Mar 2016)|
Cavally virus and other viruses from the family Mesoniviridae are divergent members of the Nidovirales, which includes coronaviruses. Polyprotein processing requires a C3-like peptidase only distantly related to the coronavirus peptidase ( C30).
|Active site||Site-directed mutagenesis has identified His1434 and Cys1539 to be the catalytic dyad (Blanck et al., 2014).|
|Activities and specificities||The 3C-like peptidase (#C107.001#) processes the large polyproteins pp1a and pp1ab. Autocatalytic release of the peptidase occurs by cleavage at -Asn-Lys+Ser- and -Asn-Gln+Ser- bonds, and presence of Asn in P2 may be a requirement (Blanck et al., 2014).|
|Inhibitors||Inhibitors have not been described.|
|Molecular structure||No tertiary sytructure has yet been solved. From the arrangement of catalytic dyad, family C107 in included in clan PA, subclan PA(C).|