Family C24


Summary Holotypes Alignment Tree Genomes Structure Literature

Summary for family C24

Family type peptidaseC24.001 - rabbit hemorrhagic disease virus 3C-like peptidase (rabbit hemorrhagic disease virus), MEROPS Accession MER0002136 (peptidase unit: 1109-1251)
Content of familyPeptidase family C24 contains cysteine endopeptidases of single-stranded RNA viruses.
History Identifier created: Perspect.Drug Discov.Des. 6:1-11 (1996)
Catalytic typeCysteine
Active site residuesH1135 D,E1152 C1212 
Active siteCatalytic triad residues His1135, Asp1152 and Cys1212 (numbered as in the MEROPS alignment) have been identified by mutagenesis (Boniotti et al., 1994) and by similarity to other peptidases in subclan PA(C).
Activities and specificitiesThe only substrate known for peptidases in family C24 is the viral polyprotein, which is cleaved in trans, and perhaps also in cis. The majority of the identified cleavage sites have Glu in P1, and the remainder, Gln. The P1" residue is commonly Gly (Myers et al., 2004).
Molecular structureThe family includes some of the smallest peptidases in subclan PA(C), the rabbit hemorrhagic disease virus enzyme containing only about 142 residues. No tertiary structure has been reported.
Basis of clan assignmentActive site residues for members of this family and family S1 occur in the same order in the sequence: H, D, C/S.
Distribution of family Bacteria -  
Archaea -  
Protozoa -  
Fungi -  
Plants -  
Animals -  
Viruses details  
Biological functionsIt is very likely that the enzymes are responsible for all the processing cleavages of their respective viruses. Caliciviruses cause diseases in human and other mammals.
Statistics for family C24Sequences:26
Identifiers with PDB entries:1
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Peptidases and Homologues MEROPS ID Structure
rabbit hemorrhagic disease virus 3C-like peptidaseC24.001-
feline calicivirus 3C-like peptidaseC24.002-
sapovirus 3C-like peptidaseC24.003Yes
family C24 non-peptidase homologuesnon-peptidase homologue-
family C24 unassigned peptidasesunassigned-