|Family type peptidase||C36.001 - beet necrotic yellow vein furovirus-type papain-like peptidase (beet necrotic yellow vein virus), MEROPS Accession MER0002121 (peptidase unit: 1283-1389)|
|Content of family||Peptidase family C36 contains a putative papain-like peptidase.|
Identifier created: Perspect.Drug Discov.Des. 6:1-11 (1996)|
Beet necrotic yellow vein virus RNA 1 contains an ORF of which the translation product contains a methyl transferase domain, an NTP-binding/helicase domain, a polymerase domain and a putative peptidase domain.
|Active site residues||C1293 H1384 |
|Active site||The putative peptidase domain was identified on the basis of sequence similarity to papain (Koonin et al., 1992, Rozanov et al., 1995).|
|Activities and specificities||Hehn %et al (1997) have demonstrated autocatalytic cleavage of the Beet necrotic yellow vein virus RNA 1 translation product into 150kDa and 66kDa fragments. This cleavage is thought to occur between the helicase and polymerase domains and is predicted to be 600 amino acids from the C-terminus of the protein, based on comparison with other alphavirus papain-like peptidases.|
|Basis of clan assignment||Predicted active site residues for members of this family and family C1 occur in the same order in the sequence: C, H.|