Family C62


Summary Holotypes Alignment Tree Genomes Literature

Summary for family C62

Family type peptidaseC62.001 - gill-associated virus 3C-like peptidase (gill-associated virus), MEROPS Accession MER0014143 (peptidase unit: 2832-3126)
Content of familyPeptidase family C62 contains a viral polyprotein-processing endopeptidase.
History Identifier created: MEROPS 6.20 (24 March 2003)
The first peptidase in the family was discovered in a virus that affects the Black Tiger Prawn (Penaeus monodon) (Cowley et al., 2000).
Catalytic typeCysteine
Active site residuesH2879 C2968 
Active siteResidues His2879 and Cys2968 (see the Alignment) were identified by mutagenesis and suggested to form a simple catalytic dyad; no evidence was obtained for a catalytic triad involving an Asp residue (Ziebuhr et al., 2003).
Activities and specificitiesA tentative cleavage consensus site has been defined as -Val-Xaa-His-GluYaa, in which Yaa is Leu or Val (Ziebuhr et al., 2003). The specificity is quite distinctive, but the P2 His specificity is seen also in some plant potyvirus NIa peptidases (family C4).
Molecular structureIn sequence, the peptidase is closest to the viral 'main' endopeptidases of coronaviruses (family C30), but the specificity is more like that of enzymes from plant potyviruses.
Distribution of family Bacteria -  
Archaea -  
Protozoa -  
Fungi -  
Plants -  
Animals -  
Viruses details  
Biological functionsThe peptidase is predicted to be the key enzyme in the processing of the GAV replicase polyprotein precursors, pp1a and pp1ab (Ziebuhr et al., 2003).
Statistics for family C62Sequences:2
Identifiers with PDB entries:0
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Peptidases and Homologues MEROPS ID Structure
gill-associated virus 3C-like peptidaseC62.001-
family C62 unassigned peptidasesunassigned-