|Family type peptidase||C62.001 - gill-associated virus 3C-like peptidase (gill-associated virus), MEROPS Accession MER0014143 (peptidase unit: 2832-3126)|
|Content of family||Peptidase family C62 contains a viral polyprotein-processing endopeptidase.|
Identifier created: MEROPS 6.20 (24 March 2003)|
The first peptidase in the family was discovered in a virus that affects the Black Tiger Prawn (Penaeus monodon) (Cowley et al., 2000).
|Active site residues||H2879 C2968 |
|Active site||Residues His2879 and Cys2968 (see the Alignment) were identified by mutagenesis and suggested to form a simple catalytic dyad; no evidence was obtained for a catalytic triad involving an Asp residue (Ziebuhr et al., 2003).|
|Activities and specificities||A tentative cleavage consensus site has been defined as -Val-Xaa-His-GluYaa, in which Yaa is Leu or Val (Ziebuhr et al., 2003). The specificity is quite distinctive, but the P2 His specificity is seen also in some plant potyvirus NIa peptidases (family C4).|
|Molecular structure||In sequence, the peptidase is closest to the viral 'main' endopeptidases of coronaviruses (family C30), but the specificity is more like that of enzymes from plant potyviruses.|