Family C63


Summary Holotypes Alignment Genomes Literature

Summary for family C63

Family type peptidaseC63.001 - African swine fever virus processing peptidase (African swine fever virus), MEROPS Accession MER0027602 (peptidase unit: 168-269)
Content of familyPeptidase family C63 contains endopeptidases.
History Identifier created: MEROPS 6.20 (24 March 2003)
Lopez-Otin et al., 1989 pointed out that the polyproteins of the African swine fever virus (ASFV) are processed at consensus -Gly-GlyXaa- sites, and the virally-encoded processing peptidase (C63.001) was subsequently characterised.
Catalytic typeCysteine
Active site residuesH168 N187 Q226 C232 
Active siteThe ASFV peptidase contains near its C-terminus a sequence of about 90 amino acids that includes catalytic residues typical of clan CE (see the Alignment). The activity of the peptidase is abolished by mutation of either His168 or Cys232 (Andres et al., 2001).
Activities and specificitiesThe two polyproteins of the virus are cleaved at -Gly-GlyXaa- sites to produce six major structural components of mature virions.
InhibitorsInhibitors include N-ethylmaleimide and Z-Leu-Val-GlyCHN2.
Molecular structureNo structure is yet available, but the sequence at the active site and the substrate specificity are both entirely consistent with membership of clan CE.
Distribution of family Bacteria -  
Archaea -  
Protozoa -  
Fungi -  
Plants -  
Animals -  
Viruses details  
Biological functionsThe activity of the AFSV peptidase is required for the maturation of the virus.
Pharmaceutical and biotech relevanceLike other viral processing peptidase, AFSV peptidase could be a drug target for control of the virus.
ReviewsAlejo et al., 2004
Statistics for family C63Sequences:1
Identifiers with PDB entries:0
Downloadable files Sequence library (FastA format)
Peptidases and Homologues MEROPS ID Structure
African swine fever virus processing peptidaseC63.001-
family C63 unassigned peptidasesunassigned-