Family C69

Family

Summary Holotypes Alignment Tree Genomes Literature H-seq M-seq

Summary for family C69

Family type peptidaseC69.001 - dipeptidase A (Lactobacillus helveticus), MEROPS Accession MER0002163 (peptidase unit: 6-474)
Content of familyPeptidase family C69 contains dipeptidases and aminopeptidases.
History Identifier created: MEROPS 6.5 (22 December 2003)
Catalytic typeCysteine
Active site residuesC6 
Active siteCatalytic residues were tentatively identified by sequence comparison with penicillin V acylase (C59.001) and other N-terminal nucleophile hydrolases (Pei & Grishin, 2003). The alignments highlighted the conservation of two regions of hydrophobic residues located between the catalytic Cys and the conserved Arg/Lys and Asp residues (see the Alignment).
Activities and specificitiesIt has been demonstrated that dipeptidase A (C69.001) is able to cleave LeuLeu and PheLeu, but not Leu-Leu-NH2 and Phe-Leu-NH2, indicating that the enzyme can only cleave dipeptides with a free C-terminus (Dudley & Steele, 2004). The peptidase is also unable to cleave bonds involving proline (Vesanto et al., 1996).
InhibitorsDipeptidase A (C69.001) is inhibited by p-hydroxymercuribenzoate (Vesanto et al., 1996).
Molecular structureNo three-dimensional structure is available for any member of the family. The molecular mass of native dipeptidase A was estimated to be 420 kDa and the monomeric mass deduced as 53.5 kDa, suggesting that dipeptidase A is an octamer (Vesanto et al., 1996).
ClanPB
SubclanPB(C)
Distribution of family Bacteria details  
Archaea details  
Protozoa details  
Fungi details  
Plants details  
Animals details  
Viruses -  
Biological functions
Statistics for family C69Sequences:2376
Identifiers:6
Identifiers with PDB entries:0
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Peptidases and Homologues MEROPS ID Structure
dipeptidase AC69.001-
arginine aminopeptidase (Streptococcus-type)C69.002-
secernin 1C69.003-
secernin 2C69.004-
secernin 3C69.005-
CG10098 protein (Drosophila melanogaster)C69.A01-
family C69 non-peptidase homologuesnon-peptidase homologue-
family C69 unassigned peptidasesunassigned-