Family C7


Summary Holotypes Alignment Tree Genomes Literature

Summary for family C7

Family type peptidaseC07.001 - chestnut blight fungus virus p29 peptidase (Cryphonectria hypovirus), MEROPS Accession MER0000821 (peptidase unit: 1-248)
Content of familyPeptidase family C7 contains only the p29 peptidase from chestnut blight hypovirus.
History Identifier created: Biochem.J. 290:205-218 (1993)
Catalytic typeCysteine
Active site residuesC162 H215 
Active siteThe active site residues have been identified by site directed mutagenesis as Cys162 and His215 (Choi et al., 1991). There is conservation of a Gly-Tyr-Cys-Tyr motif between families C7 and C6 (see the Alignment).
Activities and specificitiesThe p29 peptidase is autocatylitically released during translation from the small polyprotein of the virus, cleaving a single GlyGly bond (Choi et al., 1991).
InhibitorsInhibitors have not been described.
Molecular structureNo structure is yet available for any peptidase in family C7.
Basis of clan assignmentActive site residues for members of this family and family C1 occur in the same order in the sequence: C, H.
Distribution of family Bacteria -  
Archaea -  
Protozoa -  
Fungi -  
Plants -  
Animals -  
Viruses details  
Biological functionsThe virus encodes two polyproteins, with the p29 peptidase found at the N-terminus of the smaller p29 polyprotein. The role of the p29 peptidase once it is released from the polyprotein is uncertain, but it has been demonstrated that the p29 peptidase contributes to the reduction in fungal pigment production, sporulation and laccase production caused by the hypovirus (Craven et al., 1993).
Statistics for family C7Sequences:7
Identifiers with PDB entries:0
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Peptidases and Homologues MEROPS ID Structure
chestnut blight fungus virus p29 peptidaseC07.001-
family C07 unassigned peptidasesunassigned-