Family C74

Family

Summary Holotypes Alignment Tree Genomes Structure Literature

Summary for family C74

Family type peptidaseC74.001 - pestivirus NS2 peptidase (bovine viral diarrhea virus 1), MEROPS Accession MER0038321 (peptidase unit: 1441-1522)
Content of familyPeptidase family C74 contains viral self-processing peptidases.
History Identifier created: MEROPS 7.4 (17 Mar 2006)
Pestiviruses are positive-strand RNA viruses closely related to human hepatitis C virus. The virus is expressed as a polyprotein that is processed by cellular and viral peptidases, the latter being the N-Pro peptidase (C53.001), the NS2 peptidase (C74.001) and the NS3 peptidase (S31.001), respectively, from the N-terminus. The NS2 peptidase seems to be equivalent to the hepatitis C virus peptidase 2 (C18.001).
Catalytic typeCysteine
Active site residuesH1447 E1461 C1512 
Active siteThe active site triad His, Glu, Cys (see the Alignment) that was identified by Lackner et al., 2004 is characteristic of clan PA(C), and shows similarity to the hepatitis C virus peptidase 2.
Activities and specificitiesThe bovine viral diarrea virus NS2 peptidase (C74.001.) is responsible for a single cleavage between NS2 and NS3 of the viral polyprotein, a cleavage that is correlated with cytopathogenicity (Lackner et al., 2006). The peptidase is activated by interaction of NS2 with "J-domain protein interacting with viral protein" (Jiv) (Rinck et al., 2001; Lackner et al., 2006).
Molecular structure
ClanPA
SubclanPA(C)
Distribution of family Bacteria -  
Archaea -  
Protozoa -  
Fungi -  
Plants -  
Animals -  
Viruses details  
Biological functionsContributes to maturation of the viral polyprotein.
Statistics for family C74Sequences:26
Identifiers:1
Identifiers with PDB entries:2
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Peptidases and Homologues MEROPS ID Structure
pestivirus NS2 peptidaseC74.001Yes
family C74 unassigned peptidasesunassignedYes