Family C8


Summary Holotypes Alignment Tree Genomes Literature

Summary for family C8

Family type peptidaseC08.001 - chestnut blight fungus virus p48 peptidase (Cryphonectria hypovirus 1), MEROPS Accession MER0000822 (peptidase unit: 271-418)
Content of familyPeptidase family C8 contains only the p48 proteinase of the chestnut blight hypovirus.
History Identifier created: Biochem.J. 290:205-218 (1993)
Catalytic typeCysteine
Active site residuesC341 H388 
Active siteThe active site residues have been identified by site directed mutagenesis as Cys341 and His388 (Shapira & Nuss, 1991)
Activities and specificitiesThe p48 endopeptidase is autocatylitically released from the small polyprotein, through cleavage of a single GlyAla bond (Shapira & Nuss, 1991).
InhibitorsInhibitors have not been described.
Molecular structureNo structure is yet available for any peptidase in family C8.
Basis of clan assignmentActive site residues for members of this family and family C1 occur in the same order in the sequence: C, H.
Distribution of family Bacteria -  
Archaea -  
Protozoa -  
Fungi -  
Plants -  
Animals -  
Viruses details  
Biological functionsThe virus encodes two polyproteins, with the p48 peptidase found at the N-terminus of the larger p48 polyprotein. The role of the p48 petidase once it is released from the polyprotein is uncertain.
Statistics for family C8Sequences:6
Identifiers with PDB entries:0
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Peptidases and Homologues MEROPS ID Structure
chestnut blight fungus virus p48 peptidaseC08.001-
family C08 unassigned peptidasesunassigned-