Family C87

Family

Summary Holotypes Alignment Tree Genomes Structure Literature

Summary for family C87

Family type peptidaseC87.001 - nairovirus deubiquitinylating peptidase (Crimean-Congo hemorrhagic fever virus), MEROPS Accession MER0100000 (peptidase unit: 35-153)
Content of familyPeptidase family C87 contains viral isopeptidases.
History Identifier created: MEROPS 8.00A (14 February 2008)
As reviewed by Arguello & Hiscott (2007), an aspect of the cellular response to viral infection is the production of type I interferon (IFN), a family of cytokines that signals through its cognate IFN receptors and the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, leading to the expression of hundreds of genes with antiviral activity. Detection of viral components by the Toll-like receptor (TLR) system or the cytoplasmic RNA helicases RIG-I and Mda5 activates the IFN pathway by signaling to the kinases IKKepsilon/TBK1 to phosphorylate interferon regulatory factors 3 and 7 (IRF3/IRF7) and induce expression of IFN and IFN-stimulated genes (ISGs). Simultaneously, the inflammatory response is triggered through the IkappaB kinase (IKK) complex, leading to proteasomal degradation of the inhibitor of NF-kappaB (IkappaB), release of NF-kappaB, and transcriptional stimulation of NF-kappaB target genes. Antagonism of this system by viral enzymes that remove ubiquitin and ISG15 from proteins can allow downregulation of both the antiviral and inflammatory responses.
Catalytic typeCysteine
Active site residuesC40 H151 D153 
Active siteActive site residues (see the Alignment) were predicted by analogy with those in the 'OTU' domains (Pfam family PF02338) of several families in clan CA, and confirmed by mutagenesis (Frias-Staheli et al., 2007).
Activities and specificitiesThe peptidases have deubiquitinylase and deISGylase activities (Frias-Staheli et al., 2007).
Molecular structureFamily C87 is assigned to clan CA on the basis of the arrangement of active site residues in the sequence.
ClanCA
Distribution of family Bacteria -  
Archaea -  
Protozoa -  
Fungi -  
Plants details  
Animals details  
Viruses details  
Biological functionsExpression of the nairovirus deuquitinylating peptidase antagonizes the antiviral effects of interferon-stimulated gene product 15 (ISG15) and enhanced susceptibility to Sindbis virus infection in vivo (Frias-Staheli et al., 2007). The nairoviruses and arteriviruses proteins also inhibited NF-kappaB-dependent signaling.
Statistics for family C87Sequences:14
Identifiers:1
Identifiers with PDB entries:1
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Peptidases and Homologues MEROPS ID Structure
nairovirus deubiquitinylating peptidaseC87.001Yes
family C87 unassigned peptidasesunassigned-