Family C98


Summary Holotypes Alignment Tree Genomes Literature H-seq M-seq

Summary for family C98

Family type peptidaseC98.001 - USPL1 peptidase (Homo sapiens), MEROPS Accession MER0407721 (peptidase unit: 229-499)
Content of familyFamily C98 contains isopeptidases that release SUMO from conjugated proteins
History Identifier created: MEROPS 9.8 (17 December 2012)
The human USPL1 ('ubiquitin-specific protease-like 1', C98.001) has been characterized as a desumoylating enzyme (Schulz et al., 2012). Families C48 and C98 also contain peptidases that release SUMO from conjugated proteins (Hickey et al., 2012).
Catalytic typeCysteine
Active site residuesC236 H456 D472 
Active siteThe catalytic triad Cys236, His456 and Asp472 has been identified by sequence comparison with members of family C19 (Schulz et al., 2012). Mutagenesis of Trp229 and Trp237 residues in human USPL1 has implicated these residues in substrate binding because mutants failed to bind or cleave SUMO conjugates (Schulz et al., 2012).
Activities and specificitiesBesides acting as an isopeptidase, USPL1 also acts as a normal peptidase being able to release SUMO from its precursor (Schulz et al., 2012). USLP1 does not bind or cleave ubiquitin conjugates (Schulz et al., 2012).
Molecular structureNo tertiary structure has yet been solved for any member of family C98. The family is, however, believed to be distantly related to family C19 and hence is a member of clan CA. Surprisingly, the three families of deSUMOlatying peptidases are members of three different clans despite being the same catalytic type.
Distribution of family Bacteria -  
Archaea -  
Protozoa -  
Fungi -  
Plants -  
Animals details  
Viruses -  
Biological functions
ReviewsHickey et al., 2012
Statistics for family C98Sequences:209
Identifiers with PDB entries:0
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Peptidases and Homologues MEROPS ID Structure
USPL1 peptidaseC98.001-
family C98 non-peptidase homologuesnon-peptidase homologue-
family C98 unassigned peptidasesunassigned-