Family M57

Family

Summary Holotypes Alignment Tree Genomes Literature

Summary for family M57

Family type peptidaseM57.001 - prtB g.p. (Myxococcus xanthus) (Myxococcus xanthus), MEROPS Accession MER0004914 (peptidase unit: 1-265)
Content of familyPeptidase family M57 contains an endopeptidase.
History Identifier created: MEROPS 5.61 (29 October 2001)
Catalytic typeMetallo
Active site residuesH190 E191 H194 H200 
Active siteThe deduced amino acid sequence shows a motif HEXXHXXGXXH/ "Met-turn" characteristic of peptidases in clan MA, subclan M (the metzincins) (Quillet et al., 1997). In this, the three histidine residues would be ligands of a zinc atom, and the glutamate would have a catalytic role (see the Alignment).
Activities and specificitiesThe gene encoding the prtB peptidase has the prtA gene encoding a putative serine peptidase immediately adjacent. Only when both genes were expressed together in Escherichia coli was peptidase activity detectable (Quillet et al., 1997).
Molecular structure
ClanMA
SubclanMA(M)
Basis of clan assignmentPredicted active site residues for members of this family and thermolysin, the type example for clan MA, occur in the motif HEXXH
Distribution of family Bacteria details  
Archaea -  
Protozoa -  
Fungi -  
Plants -  
Animals details  
Viruses -  
Biological functions
Statistics for family M57Sequences:58
Identifiers:1
Identifiers with PDB entries:0
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Peptidases and Homologues MEROPS ID Structure
prtB g.p. (Myxococcus xanthus)M57.001-
family M57 unassigned peptidasesunassigned-