Family M61


Summary Holotypes Alignment Tree Genomes Literature H-seq M-seq

Summary for family M61

NamePeptidase family M61 (glycyl aminopeptidase family)
Family type peptidaseM61.001 - glycyl aminopeptidase (Sphingomonas capsulata), MEROPS Accession MER0014496 (peptidase unit: 1-641)
Content of familyPeptidase family M61 contains an aminopeptidase.
History Identifier created: MEROPS 5.61 (29 October 2001)
Catalytic typeMetallo
Active site residuesH305 E306 H309 E339 
Active siteThe active site residues of glycyl aminopeptidase (M61.001) are located in an HEXXH motif. It is possible that the conserved Glu, 30 residues to the C-terminus of the HEXXH motif, is the third metal ligand.
Activities and specificitiesGlycyl aminopeptidase hydrolyses a broad range of N-terminal amino acids, but shows a preference for glycine or alanine (Byun et al., 2001).
Inhibitors1,10-Phenanthroline has been demonstrated to have an inhibitory effect (Byun et al., 2001).
Molecular structureGlycyl aminopeptidase is a 66-kDa protein. It is thought that the first 32 residues of the protein constitute a signal peptide that directs the nascent polypeptide into the periplasm (Byun et al., 2001).
Basis of clan assignmentPredicted active site residues for members of this family and thermolysin, the type example for clan MA, occur in the motif HEXXH
Distribution of family Bacteria details  
Archaea details  
Protozoa details  
Fungi details  
Plants details  
Animals details  
Viruses -  
Biological functionsGlycyl aminopeptidase is a secreted enzyme whose primary function is thought to be in the degradation of extracellular proteins, enabling the efficient uptake of essential amino acids (Byun & Blinkovsky, 2004).
Statistics for family M61Sequences:3401
Identifiers with PDB entries:0
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Peptidases and Homologues MEROPS ID Structure
glycyl aminopeptidaseM61.001-
BcepAP aminopeptidase (Burkholderia cepacia)M61.002-
family M61 non-peptidase homologuesnon-peptidase homologue-
family M61 unassigned peptidasesunassigned-