Family M77


Summary Holotypes Alignment Tree Genomes Structure Literature

Summary for family M77

Family type peptidaseM77.001 - tryptophanyl aminopeptidase 7-DMATS-type peptidase (Aspergillus fumigatus), MEROPS Accession MER0066227 (peptidase unit: 1-472)
Content of familyFamily M77 contains aminopeptidases.
History Identifier created: MEROPS 8.3 (22 December 2008)
The dimethylallyltryptophan synthase 7-DMATS (M77.001) catalyzes the prenylation of L-tryptophan at position C7 of the indole ring. In a study of potential substrates, it was discovered that 7-DMATS could also accept tryptophan-containing cyclic dipeptides and linear dipeptides such as Trp-Gly. Two products were detected using Trp-Gly, 7-dimethylallyltryptophan and 7-dimethylallyltryptophan-Gly, which implied that 7-DMATS was also acting as a peptidase (Kremer & Li, 2008). Release of modified Trp from tetrapeptides by the prenyltransferase CdpNPT (M77.003) confirmed that the enzyme was acting as an aminopeptidase (Kremer & Li, 2008). A tryptophanyl aminopeptidase from the fungus Trichosporon cutaneum (##M9A.008##) was biochemically characterized in 1983, but has never been sequenced (Iwayama et al., 1983) and may be a homologue.
Catalytic typeMetallo
Active siteNo active site residues or metal ligands have been identified. The tryptophanyl aminopeptidase from Trichosporon cutaneum is dependent on manganese (Iwayama et al., 1983).
InhibitorsBoth 7-DMATS and FgaPT1(M77.002) are inhibited by EDTA (Kremer & Li, 2008).
Molecular structureNo tertiary structure has been solved for any member of the family.
Distribution of family Bacteria -  
Archaea -  
Protozoa -  
Fungi details  
Plants -  
Animals -  
Viruses -  
Biological functions
Statistics for family M77Sequences:197
Identifiers with PDB entries:1
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Peptidases and Homologues MEROPS ID Structure
tryptophanyl aminopeptidase 7-DMATS-type peptidaseM77.001-
tryptophanyl aminopeptidase FgaPT1 (Aspergillus fumigatus)M77.002-
tryptophanyl aminopeptidase cdpNPT-type peptidaseM77.003-
tryptophanyl aminopeptidase FtmPT1-type peptidaseM77.004Yes
family M77 non-peptidase homologuesnon-peptidase homologue-
family M77 unassigned peptidasesunassigned-