Family M84

Family

Summary Holotypes Alignment Tree Genomes Literature

Summary for family M84

Family type peptidaseM84.001 - MpriBi peptidase (Bacillus sp.) (Bacillus intermedius), MEROPS Accession MER0181727 (peptidase unit: 1-270)
Content of familyPeptidase family M84 contains endopeptidases.
History Identifier created: MEROPS 9.4 (31 January 2011)
A secreted protein known as MprBi was characterized from the soil bacterium Bacillus intermedius and shown to be a metallopeptidase (Sabirova et al., 2010).
Catalytic typeMetallo
Active site residuesH222 E223 H226 H232 
Active siteThere is a conserved HEXXHXXGXXH motif in which the three histidines have been shown to be metal ligands and the glutamate to be a catalytic residue in other members of subclan MA(M).
Activities and specificitiesThe only proteolytic activity reported is against azocasein (Sabirova et al., 2010).
InhibitorsAzocasein-cleaving activity is inhibited by metal chelators (Sabirova et al., 2010).
Molecular structureNo tertiary structure has been solved. Family M84 is included in clan MA subclan MA(M) because of the presence of the HEXXHXXGXXH motif and sequence corresponding to the structural component known as a Met-turn (Sabirova et al., 2010).
ClanMA
SubclanMA(M)
Basis of clan assignmentPredicted active site residues for members of this family and thermolysin, the type example for clan MA, occur in the motif HEXXH
Distribution of family Bacteria details  
Archaea details  
Protozoa -  
Fungi -  
Plants -  
Animals details  
Viruses -  
Biological functions
Statistics for family M84Sequences:29
Identifiers:1
Identifiers with PDB entries:0
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Peptidases and Homologues MEROPS ID Structure
MpriBi peptidase (Bacillus sp.)M84.001-
family M84 non-peptidase homologuesnon-peptidase homologue-
family M84 unassigned peptidasesunassigned-