Family S72

Family

Summary Holotypes Alignment Tree Genomes Structure Literature H-seq M-seq

Summary for family S72

Family type peptidaseS72.001 - dystroglycan (Homo sapiens), MEROPS Accession MER0054741 (peptidase unit: 603-712)
Content of familyPeptidase family S72 contains autolytic serine-type endopeptidases.
History Identifier created: MEROPS 8.2 (4 August 2008)
Dystroglycan is a component of the dystrophin-associated protein complex which may link the extracellular matrix to the cytoskeleton. Dystroglycan is a type I membrane protein which is synthesized as a precursor that is proteolytically processed into an alpha and a beta chain which remain non-covalently attached (Jayasinha et al., 2003). Cleavage occurs within a SEA domain, and is assumed to be autolytic because self-processing is known to occur in other proteins with SEA domains, such as mucin 1 (S71.001) (Akhavan et al., 2008).
Catalytic typeSerine
Active site residuesS654 
Active siteThe N-terminal residue of the beta chain, Ser654, is assumed to be the only active site residue.
Activities and specificitiesCleavage occurs at Gly653Ser within the endoplasmic reticulum (Akhavan et al., 2008).
Molecular structureNo tertiary structure has been solved for any member of the family. The dystroglycan precursor is assumed to be an N-terminal nucleophile hydrolase and family S72 may be a member of clan PB.
Clanunassigned
Distribution of family Bacteria details  
Archaea -  
Protozoa -  
Fungi -  
Plants -  
Animals details  
Viruses -  
Biological functions
Pharmaceutical and biotech relevanceMutation in the gene is associated with muscular dystrophy, and disruption of the cleavage leads to dystrophy in mouse models (Jayasinha et al., 2003). Site-directed mutations that prevent processing result in an increased capacity to bind laminin (Akhavan et al., 2008).
Statistics for family S72Sequences:367
Identifiers:2
Identifiers with PDB entries:1
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Peptidases and Homologues MEROPS ID Structure
dystroglycanS72.001Yes
dystroglycan type I (Drosophila melanogaster)S72.A01-
family S72 non-peptidase homologuesnon-peptidase homologue-
family S72 unassigned peptidasesunassigned-