Family U57


Summary Holotypes Alignment Tree Genomes Literature

Summary for family U57

Family type peptidaseU57.001 - yabG protein (Bacillus-type) (Bacillus subtilis), MEROPS Accession MER0013579 (peptidase unit: 1-290)
Content of familyPeptidase family U57 contains endopeptidases involved in bacterial sporulation.
History Identifier created: MEROPS 5.3 (4 December 2000)
Sporulation in Bacillushas been divided into stages numbered I-VII, and the stage number is included in the name of any gene that is active at that particlar stage. During stage II, the precursor of the spore, or prespore, develops and is separated from the mother cell by a septum; both mother cell and prespore each have a complete genome. During stage III the prespore becomes a forespore when the chromosome is surrounded by inner and outer membranes. Stage IV is characterized by cortex formation in which a multi-layered peptidoglucan forms between these inner and outer membranes. Sporulation is controlled by a number of σ transcription factors, principally σE, σF, σG and σK. Proteolytic processing of the precursors of σ factors occurs during stages II and IV. Other families of peptidases involved in aspects of spore production are M50, S55 and A36.
Catalytic typePeptidase of unknown catalytic type
Active siteThe nature of the active site is unknown.
Activities and specificitiesProteins SpoIVA and YrbA are degraded during stage IV of the sporulation process. Degradation does not occur in the presence of a mutant form of YabG, consistent with the possibility that YabG is a peptidase (Takamatsu et al., 2000).
InhibitorsPreliminary experiments conducted by Takamatsu et al. (2000) suggest that aprotinin (I02.001) and antipain inhibit YabG.
Molecular structure
Basis of clan assignmentProtein fold and active site residues are not known for any members of this family.
Distribution of family Bacteria details  
Archaea -  
Protozoa -  
Fungi -  
Plants -  
Animals -  
Viruses -  
Biological functionsMutational studies suggest that YabG has an important post-transcriptional role in the modification of the coat proteins of bacterial spores (Takamatsu et al., 2000).
Statistics for family U57Sequences:204
Identifiers with PDB entries:0
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Peptidases and Homologues MEROPS ID Structure
yabG protein (Bacillus-type)U57.001-
family U57 unassigned peptidasesunassigned-