Summary for peptidase A01.002: pepsin B

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

 

Names
MEROPS Namepepsin B
Other namesparapepsin I, pig gastric gelatinase
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.002
Holotypepepsin B (Canis lupus familiaris), Uniprot accession Q8SQ41 (peptidase unit: 61-390), MERNUM MER0020009
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.2
EnzymologyBRENDA database
PhysiologyOccurs as an active peptidase in the dog stomach (Narita et al., 2002). May contribute to proteolysis in the vertebrate stomach.
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Pepsin_B
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternP/aeg/Ge/FScissile bondlafy/R/L/- (based on 25 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 4 12 0 1 0 0 2
Pro 17 0 0 0 0 0 1 1
Ala 0 9 2 1 4 0 1 0
Val 1 1 0 0 2 1 1 1
Leu 1 0 1 2 10 1 18 1
Ile 0 1 0 0 0 0 0 0
Met 0 0 0 1 0 0 0 0
Phe 0 0 1 20 4 0 0 0
Tyr 0 0 0 1 3 2 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 1 0 0 0 0 0 0
Thr 0 1 0 0 0 1 1 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 1 0
Asp 0 0 0 0 0 0 0 0
Glu 2 4 6 0 1 2 0 0
Lys 0 2 1 0 0 0 0 1
Arg 2 1 0 0 0 17 0 0
His 0 0 1 0 0 0 0 0