Summary for peptidase A01.008: renin-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma


MEROPS Namerenin-2
Other namesRen2 g.p. (Mus musculus), submandibular renin
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.008
Holotyperenin-2 (Mus musculus), Uniprot accession P00796 (peptidase unit: 70-401), MERNUM MER0000915
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00006
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (1 cleavage)
KnockoutChen et al. (1999) developed transgenic mice lacking the functional Ren-2 gene, and Peng et al. (2001) studied hypertension in such mice.
Pathways KEGGRenin-angiotensin system
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Ren2 1:E4 ENSMUSG00000026449 19702 MGI:97899