Summary for peptidase A01.011: penicillopepsin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

 

Names
MEROPS Namepenicillopepsin
Other namesPenicillium janthinellum aspartic proteinase, peptidase A, penicillopepsin JT-1, penicillopepsin JT-2
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.011
Holotypepenicillopepsin (Penicillium janthinellum), Uniprot accession P00798 (peptidase unit: 5-323), MERNUM MER0000921
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00009
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.20
EnzymologyBRENDA database
Proteolytic eventsCutDB database (2 cleavages)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/A/A/KScissile bond-/A/Agc/- (based on 17 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 1 0 0 2 1
Pro 1 0 0 0 0 0 0 0
Ala 2 7 9 0 3 11 5 0
Val 0 1 0 0 0 1 0 0
Leu 1 0 0 1 0 0 0 0
Ile 0 0 1 0 1 0 0 0
Met 0 0 0 0 1 0 0 0
Phe 0 0 0 0 0 0 0 1
Tyr 0 0 0 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 0 0 0 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 1 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 1 1 1 0 0 0 0 0
Glu 0 0 0 0 1 1 0 0
Lys 0 0 1 13 0 0 0 1
Arg 0 1 0 0 0 1 0 0
His 0 0 0 0 0 0 0 0