Summary for peptidase A01.012: rhizopuspepsin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

 

Names
MEROPS Namerhizopuspepsin
Other namesprotease type XVIII (Rhizopus sp.), Rhizopus aspartic proteinase, secreted aspartic proteinase, SAP1 g.p. (Rhizopus oryzae), SAP2 g.p. (Rhizopus oryzae), SAP3 g.p. (Rhizopus oryzae), SAP4 g.p. (Rhizopus oryzae)
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.012
Holotyperhizopuspepsin (Rhizopus microsporus), Uniprot accession P06026 (peptidase unit: 73-392), MERNUM MER0000922
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00010
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.21
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/-/-/- (based on 249 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 22 19 18 14 10 20 20 19
Pro 18 11 4 6 7 5 7 9
Ala 16 30 22 17 21 30 31 22
Val 14 14 14 16 17 22 20 11
Leu 25 17 17 23 35 16 29 18
Ile 17 14 18 14 20 16 12 11
Met 10 8 10 9 8 5 7 2
Phe 9 10 6 25 11 10 6 11
Tyr 8 10 5 13 13 8 7 8
Trp 5 1 2 1 2 1 2 3
Ser 13 16 13 9 8 11 14 22
Thr 19 23 17 12 15 21 21 20
Cys 0 0 0 0 0 0 0 0
Asn 10 10 5 9 9 10 10 14
Gln 5 9 14 6 6 4 13 9
Asp 8 10 17 15 15 11 10 13
Glu 13 16 25 12 13 17 14 15
Lys 22 13 27 26 15 19 13 14
Arg 8 10 10 12 9 20 8 5
His 2 5 1 8 3 1 2 6