Summary for peptidase A01.014: candidapepsin SAP1

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namecandidapepsin SAP1
Other namessecreted aspartic proteinase 1 (Candida albicans), SAP1 g.p. (Candida albicans), SAP1 proteinase (Candida albicans)
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.014
Holotypecandidapepsin SAP1 (Candida albicans), Uniprot accession P28872 (peptidase unit: 43-380), MERNUM MER0002153
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (1 cleavage)
Pharmaceutical relevanceSuggested to contribute to epithelial damage in vaginal candidiasis (Schaller et al., 2003).
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternL/V/E/lfScissile bond-/Y/L/V (based on 26 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 1 0 0 0 0 1 1
Pro 2 0 0 0 0 0 1 1
Ala 1 2 0 1 1 2 1 0
Val 0 17 0 2 2 1 0 15
Leu 16 0 2 12 6 0 19 2
Ile 0 0 1 0 2 0 1 0
Met 0 0 0 0 0 0 0 0
Phe 0 0 3 6 2 0 0 0
Tyr 0 0 0 1 2 15 0 1
Trp 0 0 0 0 1 0 0 0
Ser 1 1 0 0 0 0 0 0
Thr 0 0 0 0 1 1 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 1 0 0 0
Gln 0 0 0 0 1 1 0 0
Asp 1 1 1 0 1 0 0 0
Glu 0 0 15 0 2 1 0 0
Lys 1 0 1 2 0 0 0 1
Arg 1 1 1 1 0 3 0 0
His 0 1 1 1 0 0 1 0