Summary for peptidase A01.016: aspergillopepsin I

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Nameaspergillopepsin I
Other namesAOAP peptidase, aspergillopepsin A, aspergillopeptidase A, aspartic proteinase II-1 (Aspergillus oryzae), molsin, oryzepsin, proctase B, proteinase B, PepA g.p. (Aspergillus niger), protease type XIII (Aspergillus saitou), prtB g.p. (Aspergillus nidulans)
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.016
Holotypeaspergillopepsin I (Aspergillus saitoi), Uniprot accession Q12567 (peptidase unit: 73-394), MERNUM MER0003668
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00014
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.18
EnzymologyBRENDA database
Proteolytic eventsCutDB database (2 cleavages)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/-/-/- (based on 157 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 9 9 13 11 10 14 9 14
Pro 3 2 4 1 5 6 6 13
Ala 11 10 15 9 16 15 15 9
Val 14 6 13 5 11 15 11 10
Leu 11 17 18 19 20 18 14 11
Ile 6 12 13 5 12 12 12 4
Met 5 4 3 6 5 5 4 7
Phe 9 8 7 7 11 8 3 11
Tyr 4 7 2 7 7 8 2 3
Trp 2 2 1 1 2 0 2 1
Ser 11 12 10 7 5 7 8 6
Thr 17 16 14 6 9 11 13 6
Cys 0 0 0 0 0 0 0 0
Asn 4 2 4 5 7 2 7 3
Gln 6 5 5 7 5 3 6 6
Asp 8 3 7 8 9 6 6 15
Glu 11 9 12 16 8 9 10 9
Lys 13 13 10 21 10 12 19 11
Arg 4 12 4 7 3 2 3 4
His 6 7 1 9 2 3 5 10