Summary for peptidase A01.019: polyporopepsin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namepolyporopepsin
Other namesIrpex lacteus aspartic peptidase, Polyporus aspartic proteinase
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.019
Holotypepolyporopepsin (Polyporus tulipiferae), Uniprot accession P17576 (peptidase unit: 4-333), MERNUM MER0000940
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00427
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.29
EnzymologyBRENDA database
Proteolytic eventsCutDB database (7 cleavages)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/lf/-/flScissile bond-/-/-/p (based on 11 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 0 1 0 0 0 0 0
Pro 1 0 0 0 1 0 0 5
Ala 1 0 0 2 0 1 3 0
Val 1 1 0 0 1 1 1 1
Leu 3 5 1 3 1 1 2 1
Ile 0 1 0 0 0 0 1 0
Met 0 0 0 0 1 1 0 0
Phe 1 2 0 3 3 0 0 0
Tyr 0 0 1 0 2 2 0 1
Trp 0 0 0 0 1 0 0 0
Ser 0 1 2 1 1 0 1 0
Thr 0 0 0 1 0 0 1 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 2 0 0 2 0 1
Asp 0 0 0 0 0 0 0 0
Glu 1 0 1 0 0 1 1 0
Lys 0 0 1 1 0 2 0 1
Arg 1 1 1 0 0 0 0 0
His 1 0 1 0 0 0 1 0