Summary for peptidase A01.026: peptidase F

Summary Alignment Tree Sequences Sequence features Distribution Literature


MEROPS Namepeptidase F
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.026
Holotypepeptidase F (Aspergillus fumigatus), Uniprot accession P41748 (peptidase unit: 74-392), MERNUM MER0001437
History Identifier created: MEROPS 3.02 (25 June 1998)
Catalytic typeAspartic
NC-IUBMBNot yet included in IUBMB recommendations.
Pharmaceutical relevanceReported to be an elastinolytic aspartic proteinase secreted by the fungus during invasion of the host lung (Lee & Kolattukudy, 1995). However, lack of inhibition of elastinolytic activity by pepstatin in this study is puzzling.