Summary for peptidase A01.031: yapsin-2

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

 

Names
MEROPS Nameyapsin-2
Other namesMKC7 g.p. [obs.] (Saccharomyces cerevisiae), YPS2 g.p. (Saccharomyces cerevisiae)
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.031
Holotypeyapsin-2 (Saccharomyces cerevisiae), Uniprot accession P53379 (peptidase unit: 61-471), MERNUM MER0002653
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00021
NC-IUBMBNot yet included in IUBMB recommendations.
PhysiologyContributes to processing of protein precursors in Saccharomyces cerevisiae.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/Ye/krv/RKScissile bondE/A/E/A (based on 16 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 0 0 0 0
Pro 0 0 0 0 0 0 0 0
Ala 0 0 0 0 0 13 2 13
Val 0 0 2 0 0 1 0 0
Leu 1 0 0 0 2 0 0 0
Ile 0 0 0 0 0 0 0 0
Met 1 0 0 0 1 0 0 0
Phe 0 0 1 0 0 0 1 0
Tyr 0 10 0 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 0 0 0 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 1 0 0 0 0 0
Asp 0 1 0 0 0 2 0 0
Glu 0 3 1 0 13 0 13 2
Lys 0 1 7 5 0 0 0 0
Arg 0 0 2 10 0 0 0 0
His 1 1 0 0 0 0 0 0