Summary for peptidase A01.040: nepenthesin

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors

 

Names
MEROPS Namenepenthesin
Other namesNepenthes aspartic endopeptidase, nepenthesin-1 (Nepenthes sp.), nepenthesin-2 (Nepenthes sp.)
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A1 >> Subfamily B >> A01.040
Holotypenepenthesin (Nepenthes gracilis), Uniprot accession Q766C3 (peptidase unit: 75-437), MERNUM MER0031323
History Identifier created: MEROPS 4.0 (27 January 2000)
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00022
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.12
EnzymologyBRENDA database
PhysiologyBelieved to be responsible for digestion of insect prey by insectivorous plants in the genus Nepenthes.
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Nepenthesin
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/-/-/- (based on 19 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 2 1 0 0 1 1 2
Pro 0 1 0 0 0 0 1 1
Ala 1 1 1 3 3 3 1 1
Val 1 2 3 0 1 3 3 2
Leu 1 1 1 4 3 3 2 3
Ile 1 0 1 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 1 0 1 2 2 0 0 0
Tyr 1 1 0 3 3 2 1 1
Trp 1 1 0 0 0 0 0 0
Ser 0 1 3 0 0 1 1 0
Thr 1 1 0 1 1 1 2 0
Cys 0 0 0 0 0 0 0 0
Asn 1 0 1 1 0 0 1 0
Gln 1 1 0 1 0 0 0 0
Asp 0 3 1 2 3 1 1 1
Glu 2 1 3 1 0 3 1 1
Lys 1 1 1 0 1 1 0 1
Arg 1 1 0 0 0 0 1 2
His 1 1 2 1 1 0 0 1