Summary for peptidase A01.041: memapsin-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namememapsin-1
Other namesALP56 protein, Asp1 protease, beta-secretase (putative), beta-site APP-cleaving enzyme 2, BACE2, breast-cancer-related aspartic proteinase, Down region aspartic protease, DRAP
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.041
Holotypememapsin-1 (Homo sapiens), Uniprot accession Q9Y5Z0 (peptidase unit: 69-441), MERNUM MER0005534
History Identifier created: MEROPS 3.4 (5 November 1999)
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00023
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.45
EnzymologyBRENDA database
Proteolytic eventsCutDB database (3 cleavages)
Activity statushuman: active (Tang & Koelsch, 2004)
mouse: putative
Pharmaceutical relevanceCandidate beta-secretase in Alzheimer"s disease (together with memapsin 2). The gene maps to chromosome 21 in the so-called "Down critical region" in 21q22.3 (Acquati et al., 2000). Reported to show differential expression in human breast cancer (Xin et al., 2000).
Pathways KEGGAlzheimer's disease
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/BACE2
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patterng/-/-/-Scissile bond-/-/-/- (based on 33 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 7 1 1 3 4 2 2 3
Pro 0 1 1 1 1 2 0 2
Ala 3 4 4 1 6 3 2 2
Val 5 5 4 0 1 2 3 2
Leu 3 5 6 7 2 5 2 5
Ile 2 1 0 0 0 0 1 1
Met 1 0 1 1 0 0 0 1
Phe 0 0 2 2 4 1 4 5
Tyr 1 0 0 3 2 3 4 2
Trp 0 0 0 0 0 0 0 0
Ser 0 1 2 1 1 0 1 0
Thr 0 0 0 0 0 0 0 1
Cys 0 0 0 0 0 0 1 1
Asn 0 1 1 0 0 0 0 0
Gln 0 0 1 1 1 1 0 0
Asp 0 1 0 1 1 1 1 2
Glu 4 5 0 2 0 4 3 0
Lys 2 2 2 3 4 5 3 0
Arg 1 2 4 4 3 4 1 1
His 2 3 3 3 3 0 1 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
BACE2 21pter-qter ENSG00000182240 25825 BACE2 605668
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Bace2 1:F ENSMUSG00000040605 56175 MGI:1860440