Summary for peptidase A01.046: napsin A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors


MEROPS Namenapsin A
Other namesAsp4 protease, dap1, dap2, decidual aspartyl protease, kidney aspartic protease (Mus musculus), Mername-AA043 peptidase, TA02 protein
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.046
Holotypenapsin A (Homo sapiens), Uniprot accession O96009 (peptidase unit: 65-394), MERNUM MER0004981
History Identifier created: MEROPS 3.21 (12 May 1999)
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00024
NC-IUBMBNot yet included in IUBMB recommendations.
PhysiologyAbundantly expressed in normal human lung and kidney tissue, and particularly highly expressed in lung adenocarcinomas (Chuman et al., 1999; Hirano et al., 2000).
Pharmaceutical relevanceNapsin A has been described as a useful marker for diagnosis of primary lung adenocarcinoma (Ueno et al., 2003).
Pathways KEGGLysosome
Other databases WIKIPEDIA
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
NAPSA 19q13.33 ENSG00000131400 9476 NAPSA 605631
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Kdap 7:B2 ENSMUSG00000002204 16541 MGI:109365