Summary for peptidase A01.051: pepsin F

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Mouse EST Substrates Inhibitors


MEROPS Namepepsin F
Other namespregnancy-associated aspartic endopeptidase, pregnancy-associated glycoprotein 2, pregnancy-associated glycoprotein 12
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.051
Holotypepepsin F (Oryctolagus cuniculus), Uniprot accession P27823 (peptidase unit: 61-388), MERNUM MER0000901
History Identifier created: MEROPS 5.1 (22 June 2000)
Catalytic typeAspartic
NC-IUBMBNot yet included in IUBMB recommendations.
StructureThere are structural similarities to the pregnancy-associated glycoproteins of other species and to cathepsin E.
PhysiologyAppears in association with pregnancy in horse. Restricted to the outer chorionic cell layer in the horse placenta both prior to implantation and in the term placenta (Green et al., 1999). It seems that a pepsinogen-like ancestral proenzyme has diversified within the Artiodactyla to give rise to a large and diverse set of homologous proteins. Expression of the gene for rabbit pepsinogen F was found to be restricted to the early postnatal stage, reminiscent of other pepsins expressed in embryonic and neonatal life.
Pathways KEGGProtein digestion and absorption
Other databases TREEFAM
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Pga5 19:B ENSMUSG00000024738 58803 MGI:1915935