Summary for peptidase A01.060: candidapepsin SAP2

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namecandidapepsin SAP2
Other namessecreted aspartic proteinase 2 (Candida albicans), SAP2 g.p. (Candida albicans), SAP2 proteinase (Candida albicans)
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.060
Holotypecandidapepsin SAP2 (Candida albicans), Uniprot accession P0DJ06 (peptidase unit: 50-387), MERNUM MER0000932
History Identifier created: MEROPS 6.3 (23 June 2003)
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00429
NC-IUBMBNot yet included in IUBMB recommendations.
Pharmaceutical relevanceSuggested to contribute to epithelial damage in vaginal candidiasis (Schaller et al., 2003).
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternL/V/E/LkryScissile bond-/Y/L/V (based on 22 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 0 1 0 0 0 0 1
Pro 0 0 0 0 0 0 0 1
Ala 0 0 1 1 1 1 0 0
Val 0 16 0 0 1 0 1 16
Leu 16 0 0 12 6 0 16 0
Ile 0 0 0 0 1 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 1 0 0 1 2 1 0 1
Tyr 1 1 0 2 1 16 0 0
Trp 0 0 0 0 1 0 0 0
Ser 1 1 0 0 0 0 1 0
Thr 1 0 0 0 1 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 1 0 0 0
Asp 0 0 0 0 1 0 0 0
Glu 0 0 17 0 1 0 1 1
Lys 0 1 2 4 2 0 1 1
Arg 0 0 1 2 1 1 0 0
His 1 3 0 0 1 3 2 1