Summary for peptidase A01.068: necepsin-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors

 

Names
MEROPS Namenecepsin-2
Other namesAcasp-1 (Ancylostoma caninum), asp-4 g.p. (Caenorhabditis elegans), BmAsp-2 (Brugia malay1), Na-APR-1 g.p. (Necator americanus), nemepsin-2, R12H7.2 protein (Caenorhabditis elegans)
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.068
Holotypenecepsin-2 (Necator americanus) (peptidase unit: 82-412), MERNUM MER0013997
History Identifier created: MEROPS 6.6 (29 March 2004)
Activity
Catalytic typeAspartic
NC-IUBMBNot yet included in IUBMB recommendations.
PhysiologyThe aspartic endopeptidase of Onchocercus volvulus appears to function in intestinal digestion and tissue degradation of the filaria (Jolodar et al., 2004).
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternl/-/-/flScissile bond-/-/lh/- (based on 45 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 4 3 0 1 2 4 4 2
Pro 6 2 0 0 1 2 2 1
Ala 3 6 5 5 7 11 3 2
Val 7 6 6 3 3 2 6 8
Leu 9 2 4 11 9 5 9 5
Ile 0 2 0 0 0 0 0 0
Met 0 0 1 0 0 0 0 0
Phe 1 2 4 13 6 1 1 4
Tyr 0 0 0 0 2 1 1 1
Trp 0 0 0 1 1 0 0 0
Ser 0 1 1 2 3 5 7 5
Thr 4 3 2 2 2 1 0 1
Cys 0 2 2 1 0 0 0 1
Asn 4 3 3 1 0 0 0 1
Gln 0 3 0 0 0 1 0 0
Asp 2 3 3 1 3 0 1 2
Glu 1 3 5 1 2 3 0 1
Lys 2 2 5 2 1 3 2 1
Arg 0 1 3 0 0 3 1 0
His 1 1 1 1 2 3 8 8