Summary for peptidase A01.071: pepsin A5 (Homo sapiens)

Summary Alignment Sequences Sequence features Distribution Literature Human EST Substrates

 

Names
MEROPS Namepepsin A5 (Homo sapiens)
Other namespepsinogen A5, PGA5 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.071
Holotypepepsin A5 (Homo sapiens), Uniprot accession P0DJD9 (peptidase unit: 63-388), MERNUM MER0037291
History Identifier created: MEROPS 6.8 (20 August 2004)
Activity
Catalytic typeAspartic
NC-IUBMBNot yet included in IUBMB recommendations.
Pathways KEGGProtein digestion and absorption
Other databases TREEFAMhttp://www.treefam.org/family/TF314990
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/lScissile bond-/l/-/- (based on 10 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 2 1 0 0 0 0 1
Pro 0 1 0 0 0 0 1 1
Ala 1 1 1 1 1 0 1 0
Val 1 1 1 0 2 1 1 1
Leu 2 2 2 4 2 3 1 3
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 0 0 1 2 2 0 1 0
Tyr 0 0 0 1 2 2 1 0
Trp 0 0 0 0 0 0 0 0
Ser 0 1 0 0 0 0 0 0
Thr 0 0 1 0 0 1 1 0
Cys 0 0 0 0 0 0 1 1
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 1
Asp 0 0 0 1 0 2 0 0
Glu 2 1 1 1 0 1 1 0
Lys 0 0 1 0 1 0 1 2
Arg 2 1 0 0 0 0 0 0
His 1 0 1 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PGA5 11q13 ENSG00000172647 5222 PGA5 169720