Summary for peptidase A01.078: CnAP1 peptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature Inhibitors


MEROPS NameCnAP1 peptidase
Name and HistoryCnAP1 peptidase is an aspartic peptidase characterized from the fungus Cryptococcus neoformans (Pinti et al., 2007), the causative agent of cryptococcosis which affects AIDS patients. Treatment with inhibitors of the HIV1 retropepsin can also improve such secondary infections by also inhibiting their aspartic peptidases. However, AIDS drugs such as Indinavir, Lopinavir and Ritonavir did not inhibit digestion of BODIPY-labelled casein by CnAP1 peptidase (Pinti et al., 2007).
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.078
HolotypeCnAP1 peptidase (Cryptococcus neoformans) (peptidase unit: 134-452), MERNUM MER0079560
History Identifier created: MEROPS 7.9 (17 September 2007)
Catalytic typeAspartic
NC-IUBMBNot yet included in IUBMB recommendations.