Summary for peptidase A02.002: HIV-2 retropepsin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

 

Names
MEROPS NameHIV-2 retropepsin
Other namesHIV-2 protease, retropepsin (human immunodeficiency virus 2)
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A2 >> Subfamily A >> A02.002
HolotypeHIV-2 retropepsin (human immunodeficiency virus 2), Uniprot accession Q76634 (peptidase unit: 516-611), MERNUM MER0001468
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00026
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.47
EnzymologyBRENDA database
Proteolytic eventsCutDB database (9 cleavages)
PhysiologyProcessing of viral polyprotein of human immunodeficiency virus type 2.
Pharmaceutical relevanceDrug target for human immunodeficiency virus infection.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternS/q/Nve/yfmScissile bondpa/IE/v/Qf (based on 30 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 3 2 0 2 1 0 0 2
Pro 2 1 0 0 14 0 0 1
Ala 1 1 0 1 5 1 2 1
Val 0 1 6 0 2 0 15 0
Leu 0 2 1 3 0 0 3 0
Ile 0 1 1 0 0 16 2 0
Met 0 0 0 4 1 0 1 1
Phe 0 3 1 4 2 0 0 4
Tyr 3 1 0 11 1 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 16 0 1 1 1 0 1 0
Thr 0 0 1 0 2 1 0 0
Cys 0 0 0 0 0 0 1 0
Asn 1 0 16 1 0 1 0 0
Gln 0 10 0 0 0 1 1 15
Asp 2 1 0 0 0 0 1 1
Glu 1 3 3 1 0 10 1 0
Lys 0 1 0 0 0 0 0 0
Arg 1 2 0 0 0 0 2 2
His 0 1 0 0 0 0 0 1