Summary for peptidase A02.004: equine infectious anaemia virus retropepsin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Nameequine infectious anaemia virus retropepsin
Other namesretropepsin (equine infectious anaemia virus)
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A2 >> Subfamily D >> A02.004
Holotypeequine infectious anaemia virus retropepsin (equine infectious anemia virus), Uniprot accession P32542 (peptidase unit: 84-184), MERNUM MER0001447
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00028
NC-IUBMBNot yet included in IUBMB recommendations.
PhysiologyProcessing of viral polyprotein.
Pharmaceutical relevanceDrug target for equine swamp fever.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternS/q/N/YScissile bondP/I/V/Q (based on 13 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 1 0 0 0 0 0 0
Pro 0 0 0 0 13 0 0 0
Ala 0 1 0 0 0 0 0 0
Val 0 1 0 0 0 0 13 0
Leu 0 1 0 1 0 0 0 0
Ile 0 0 0 0 0 13 0 0
Met 0 0 0 1 0 0 0 0
Phe 0 1 0 1 0 0 0 0
Tyr 0 0 0 10 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 13 0 0 0 0 0 0 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 13 0 0 0 0 0
Gln 0 7 0 0 0 0 0 12
Asp 0 0 0 0 0 0 0 0
Glu 0 0 0 0 0 0 0 0
Lys 0 1 0 0 0 0 0 0
Arg 0 0 0 0 0 0 0 0
His 0 0 0 0 0 0 0 0