Summary for peptidase A02.005: bovine immunodeficiency virus retropepsin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS Namebovine immunodeficiency virus retropepsin
Other namesretropepsin (bovine immunodeficiency virus)
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A2 >> Subfamily A >> A02.005
Holotypebovine immunodeficiency virus retropepsin, Uniprot accession P19560 (peptidase unit: 476-575), MERNUM MER0000960
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeAspartic
NC-IUBMBNot yet included in IUBMB recommendations.
PhysiologyProcessing of viral polyprotein.
Pharmaceutical relevanceEvaluated as a model of lentivirus disease.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/q/-/-Scissile bond-/s/-/t (based on 11 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 0 0 0 0
Pro 1 0 0 1 2 0 0 0
Ala 0 0 2 1 1 2 2 1
Val 0 1 0 0 1 1 1 1
Leu 1 0 0 2 1 1 1 0
Ile 0 1 1 0 0 0 1 0
Met 1 1 0 1 2 0 0 2
Phe 0 0 1 2 0 0 0 0
Tyr 0 0 1 2 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 1 2 2 0 2 4 2 1
Thr 2 0 0 0 0 0 2 4
Cys 0 0 0 0 0 0 0 0
Asn 0 1 3 1 0 0 0 1
Gln 2 4 1 0 0 2 1 1
Asp 0 0 0 0 0 0 0 0
Glu 0 1 0 0 0 0 1 0
Lys 2 0 0 1 1 1 0 0
Arg 0 0 0 0 0 0 0 0
His 1 0 0 0 1 0 0 0
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
6:A1