Summary for peptidase A02.007: feline immunodeficiency virus retropepsin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namefeline immunodeficiency virus retropepsin
Other namesretropepsin (feline immunodeficiency virus)
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A2 >> Subfamily A >> A02.007
Holotypefeline immunodeficiency virus retropepsin, Uniprot accession P31822 (peptidase unit: 46-153), MERNUM MER0000965
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00029
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (8 cleavages)
PhysiologyProcessing of viral polyprotein.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternapt/qr/Vatq/ylmScissile bondpy/ie/qai/tsv (based on 28 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 2 0 0 0 0 0 2
Pro 6 0 0 0 7 0 0 0
Ala 7 0 6 0 2 3 5 2
Val 0 0 14 0 2 3 1 4
Leu 0 2 0 4 2 0 0 1
Ile 0 0 0 0 0 11 4 0
Met 0 3 0 4 2 0 0 0
Phe 0 2 0 3 0 0 0 0
Tyr 0 0 0 8 4 0 0 0
Trp 0 0 0 2 0 0 2 0
Ser 1 0 0 0 2 2 0 5
Thr 5 0 4 0 0 0 0 6
Cys 2 0 0 0 0 0 0 0
Asn 0 0 1 2 0 2 0 0
Gln 0 9 3 3 0 2 9 1
Asp 0 0 0 0 0 0 2 0
Glu 0 2 0 0 0 5 3 2
Lys 3 3 0 0 1 0 2 0
Arg 2 5 0 0 0 0 0 0
His 0 0 0 0 0 0 0 0