Summary for peptidase A02.008: murine leukemia virus-type retropepsin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

 

Names
MEROPS Namemurine leukemia virus-type retropepsin
Other namesMoloney murine leukemia virus-type retropepsin, retropepsin (Moloney murine leukemia virus), xenotropic murine leukemia virus-related virus (XMRV) retropepsin
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A2 >> Subfamily A >> A02.008
Holotypemurine leukemia virus-type retropepsin (Moloney murine leukemia virus), Uniprot accession P03355 (peptidase unit: 535-659), MERNUM MER0001480
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00030
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (5 cleavages)
PhysiologyProcessing of viral polyprotein.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternS/q/N/YlftScissile bondP/Il/V/Q (based on 20 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 1 0 0 0 0 0 0
Pro 0 0 1 0 14 0 0 0
Ala 1 1 2 0 0 1 0 0
Val 0 1 3 0 1 0 12 0
Leu 2 3 2 4 0 5 1 1
Ile 2 1 0 1 0 12 1 1
Met 0 0 0 1 1 0 1 0
Phe 0 1 0 2 0 0 0 0
Tyr 0 0 0 10 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 14 1 0 0 0 0 1 1
Thr 1 1 0 2 2 1 0 3
Cys 0 0 0 0 0 0 0 0
Asn 0 0 12 0 0 1 1 0
Gln 0 9 0 0 0 0 1 12
Asp 0 0 0 0 0 0 0 1
Glu 0 0 0 0 2 0 1 1
Lys 0 1 0 0 0 0 0 0
Arg 0 0 0 0 0 0 1 0
His 0 0 0 0 0 0 0 0
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Mela 8 E1 ENSMUSG00000074036 17276 MGI:107565