Summary for peptidase A02.009: Mason-Pfizer leukemia virus retropepsin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS NameMason-Pfizer leukemia virus retropepsin
Other namessquirrel monkey retrovirus protease, retropepsin (Mason-Pfizer leukemia virus), rhesus monkey immunodeficiency virus retropepsin, retropepsin (rhesus monkey immunodeficiency virus)
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A2 >> Subfamily A >> A02.009
HolotypeMason-Pfizer leukemia virus retropepsin (Mason-Pfizer monkey virus), Uniprot accession P07570 (peptidase unit: 167-269), MERNUM MER0000969
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00031
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (4 cleavages)
PhysiologyProcessing of viral polyprotein.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternS/q/Nv/YScissile bondP/Iva/V/Q (based on 18 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 1 0 0 1 0 0 0
Pro 3 0 0 0 13 0 0 0
Ala 0 1 1 0 2 2 0 1
Val 0 1 4 0 0 4 15 0
Leu 0 1 0 1 0 0 0 0
Ile 0 0 1 0 0 12 0 0
Met 0 0 0 3 0 0 0 0
Phe 0 1 0 2 0 0 0 0
Tyr 0 0 0 12 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 12 0 0 0 0 0 0 1
Thr 0 1 0 0 0 0 1 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 12 0 0 0 0 1
Gln 0 10 0 0 0 0 0 12
Asp 0 1 0 0 0 0 0 0
Glu 0 0 0 0 0 0 0 1
Lys 2 1 0 0 0 0 0 2
Arg 0 0 0 0 0 0 2 0
His 1 0 0 0 0 0 0 0
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
12