Summary for peptidase A02.010: mouse mammary tumor virus retropepsin

Summary Alignment Sequences Sequence features Distribution Literature Substrates Inhibitors

 

Names
MEROPS Namemouse mammary tumor virus retropepsin
Other namesretropepsin (mouse mammary tumor virus)
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A2 >> Subfamily A >> A02.010
Holotypemouse mammary tumor virus retropepsin, Uniprot accession P10271 (peptidase unit: 165-266), MERNUM MER0000970
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (2 cleavages)
PhysiologyProcessing of viral polyprotein.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternS/qfkl/N/yflmScissile bondP/I/V/Q (based on 13 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 0 0 0 0
Pro 0 0 0 0 12 0 0 0
Ala 0 0 1 0 0 1 0 0
Val 0 1 0 0 0 2 11 0
Leu 0 2 0 2 1 0 0 0
Ile 0 0 1 0 0 10 0 0
Met 0 0 0 2 0 0 0 0
Phe 0 2 0 3 0 0 0 1
Tyr 0 0 0 6 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 11 0 0 0 0 0 0 0
Thr 1 0 1 0 0 0 1 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 10 0 0 0 0 0
Gln 0 6 0 0 0 0 0 10
Asp 0 0 0 0 0 0 0 1
Glu 1 0 0 0 0 0 0 0
Lys 0 2 0 0 0 0 1 0
Arg 0 0 0 0 0 0 0 1
His 0 0 0 0 0 0 0 0