Summary for peptidase A02.011: human endogenous retrovirus K retropepsin

Summary Alignment Sequences Sequence features Distribution Literature Human EST Substrates Inhibitors

 

Names
MEROPS Namehuman endogenous retrovirus K retropepsin
Other nameshuman endogenous retrovirus K10 endopeptidase, HERV K10 endopeptidase
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A2 >> Subfamily A >> A02.011
Holotypehuman endogenous retrovirus K retropepsin (Homo sapiens), Uniprot accession P63127 (peptidase unit: 5-106), MERNUM MER0000968
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00032
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.50
EnzymologyBRENDA database
Pharmaceutical relevanceActivities of endogenous retroviruses in the brain may be relevant to schizophrenia (Yolken et al., 2000). Inhibitors of human endogenous retrovirus K retropepsin have been described (Kuhelj et al., 2001).
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
5 ENSG00000184379